This comprehensive report by the Lancet Commission provides updated evidence on dementia prevention, intervention, and care. It identifies 14 modifiable risk factors across the life course, suggesting that up to 45% of dementia cases could be prevented or delayed. The report emphasizes the importance of early-life education, midlife and late-life...

This comprehensive review outlines a structured diagnostic approach to adult-onset neurometabolic diseases, emphasizing clinical presentations, biochemical markers, neuroimaging findings, and the importance of early recognition for effective treatment.

This study reports a novel mutation in the optineurin (OPTN) gene associated with aggressive amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The findings expand the genetic spectrum of ALS/FTD and suggest that OPTN mutations can lead to rapidly progressive neurodegenerative phenotypes.

This article discusses Niemann-Pick type C disease, its contemporary diagnosis, and treatment approaches. The condition, a rare genetic disorder, affects lipid metabolism and causes neurological decline. This review article provides an updated overview of Niemann-Pick type C, focusing on its clinical presentation, diagnostic challenges, and evolving treatment strategies. It discusses...