This comprehensive report by the Lancet Commission provides updated evidence on dementia prevention, intervention, and care. It identifies 14 modifiable risk factors across the life course, suggesting that up to 45% of dementia cases could be prevented or delayed. The report emphasizes the importance of early-life education, midlife and late-life health interventions, and equitable access to care. It also discusses advances in diagnosis, treatment, and the need for culturally sensitive approaches to dementia care.