This comprehensive report by the Lancet Commission provides updated evidence on dementia prevention, intervention, and care. It identifies 14 modifiable risk factors across the life course, suggesting that up to 45% of dementia cases could be prevented or delayed. The report emphasizes the importance of early-life education, midlife and late-life...

This study reports a novel mutation in the optineurin (OPTN) gene associated with aggressive amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The findings expand the genetic spectrum of ALS/FTD and suggest that OPTN mutations can lead to rapidly progressive neurodegenerative phenotypes.